College football picks, schedule: Predictions against the spread, odds for top 25 games in Week 4

No. 3 Ohio State and No. 4 Michigan will try to keep strong starts going against teams they’ve dominated in recent years. There’s plenty to prove for No. 10 Arkansas, No. 11 Tennessee and Wake Forest as they seek more respect within their respective divisional races against ranked conference opponents. No. 5 Clemson at No. 21 Wake Forest has found outright success or at least more competitive results against every other ACC team except for the Tigers, and the reason comes down to a major disadvantage at the line of scrimmage.

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