Explaining the Most Baffling Quirk of COVID: Common Gene Variant Linked to Mortality

A new research paper published on September 21 in the journal Nature may explain the genetic underpinnings of COVID-19. Scientists showed that mice with gene variants previously linked to Alzheimer’s disease were at a greater risk of dying when infected with SARS-CoV-2. With 3% of the world population possessing these gene variants, the findings may have implications for hundreds of millions of individuals worldwide. People with APOE2 or APOE4 produce proteins that differ from APOE3 protein by one or two amino acids.

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