Obesity May Be a Neurodevelopmental Disorder

Obesity is, in part, determined by epigenetic development in the arcuate nucleus of the hypothalamus. Epigenetics is a system of molecular bookmarking that determines which genes will, or will not, be used in different cell types. The team reports in the journal Science Advances that molecular mechanisms of brain development during early life are likely a major determinant of obesity risk. Prevention efforts targeting these developmental processes could be the key to stopping the worldwide obesity epidemic, the authors say. The authors are affiliated with the following institutions: Baylor College of Medicine, Vanderbilt University and Vanderbilt University.

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