Calcium Channels Regulate Neuroinflammation and Neuropathic Pain

The Orai1 class of calcium channels regulates sex differences in the functioning of immune cells associated with neuroinflammation and neuropathic pain. Microglia are the primary immune cells of the brain and resemble macrophages found in the peripheral immune system. In healthy brains, microglia influence the formation of synapses, or connections, between neurons that impact neural circuits and regulate overall cognitive functions.

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